Gastroprotective activity of yogurt fortified with purple roselle extract in rats exposed with 2,3,7,8-TCDD

نویسندگان

چکیده

Persistent organic pollutant 2,3,7,8-Tetrachlorodiobenzo-p-dioxin (TCDD), known as harmful congeners of dioxin, has many adverse effects on human or animal health. This TCDD enters the body through inhalation, ingestion, and skin contact. Purple Roselle is a well-known herb-medicinal plant having antioxidant properties. study aimed to evaluate capacity purple roselle water extract along yogurt against dioxin exposure. The properties were measured by malondialdehyde (MDA) levels gastrointestinal histology. For this, 25 white male rats (Rattus norvegicus) used, these divided into five groups negative control, positive control (TCDD 200 ng/kg BW), three treatment BW + fortified with concentrations 0.5, 1, 1.5 percent), all treatments given orally. Gastric MDA was determined quantitatively using Thiobarbituric Acid (TBA) method one-way ANOVA test, continued Tukey post hoc test confidence level 95% while gastric histology observed descriptively. Results revealed that supplementation 1% could dramatically reduce (p<0,05) heal histological damage in lamina propria mucosa stomach subjected TCDD. can be concluded consuming repair caused

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ژورنال

عنوان ژورنال: Journal of Experimental Biology and Agricultural Sciences

سال: 2022

ISSN: ['2320-8694']

DOI: https://doi.org/10.18006/2022.10(6).1486.1491